Purpose of study is the testing Azinofen for its efficacy and biosafety in experimental canine echinococcosis. The therapeutic dose and the parameters of the Azinofen efficacy and biosafety were determined by the method of individual application, once at a dose of 5.0; 7.5 and 10.0 mg/kg, mixed with minced meat, on 12 outbred dogs aged 7-10 months, infected with echinococcosis. The use of Azinofen once at a dose of 10.0 mg/kg of body weight showed on the 5th day its 100 % efficiency. In a 7, 10 and 14 days of research, no teniids-type eggs were found in the faeces. It has been established that the echinococcosis invasion has a mechanical, toxic and inoculatory effect on the tissues of the small intestine of dogs, and negatively affects the morpho-biochemical composition of the blood. The experiments confirmed that the blood levels of erythrocytes, leukocytes, hemoglobin, total protein (including serum albumin and globulins), macroelements (calcium and phosphorus) treated with Azinofen at a dose of 10.0 mg/kg live weights, once on the 7th-10th day of the experiment, corresponded to physiological norms. The data obtained confirm the high efficiency of preparations based on the substances of praziquantel, fenbendazole in cestodosis invasions.