Ticks of the family Ixodidae are blood-sucking ectoparasites, they carry and accumulate many infections that are dangerous for all species of mammals. Particularly sensitive damage is caused to agriculture and animal husbandry during the peak activity of ticks, which occur in spring and autumn in the central region of the Russian Federation. Outbreaks of diseases of small domestic and farm animals: anaplasmosis, nuttalliosis, babesiosis, pyroplasmosis, etc. are recorded all over the world annually. Borreliosis (Lyme disease), tickborne encephalitis virus, etc. are especially common among people. Without timely preventive work and treatment, animals die. The situation is exacerbated by the fact that arthropods, including ixodid ticks, are able to develop resistance to various active substances after a while, and the effectiveness of preventive treatments is reduced. Therefore, the development and implementation of new acaricidal drugs is very relevant. The article presents the results of laboratory tests of the drug in the form of a polymer material based on sphenvalerate and piperonyl butoxide and a solution based on cythuthrin against ixodid ticks of the species Ixodes ricinus and Dermacentor reticulatus, collected in natural biotopes of the Kaluga region. As a result of laboratory tests of acaricides, positive results were obtained on the acaricidal activity of drugs. Participation in the experiment of natural ixodid ticks collected in the Kaluga region indicates the effectiveness of the drug on ticks living in nearest areas, taking into account the biological and environmental characteristics of ixodid ticks and the possibility of active implementation in practice for preventive purposes