Pathogenetically adequate therapy for hepatorenal system disorders in cats with urolithiasis should have a well-adjusted correction algorithm taking into account the nature of metabolic disorders and oxidative changes in the diseased animal organism and be based on the use of etiotropic therapy, hepatoprotectors against the background of symptomatic therapy using dietary therapy. As a result of our studies, we proved the high therapeutic efficacy of the developed complex scheme for pharmacocorrection of hepatorenal system disorders in cats with tripelphosphateurolithiasis, using convention, urolex, D-mannose, cranberry extract and heptral against the background of diet therapy. Based on the morphological and biochemical studies of blood, the data of the urological status and ultrasonographic parameters, it was found that the pharmacological correction scheme has a pronounced reparative effect and helps optimize the functions of the hepatorenal system, which was manifested by an increase in the number of red blood cells and hemoglobin, a decrease in the number of leukocytes, optimization of the electrolyte composition of blood, normalization indicators of carbohydrate and protein metabolism, a decrease in urea content to 8.3 ± 1,0 mmol / l and creatinine - up to 141,9 ± 2.2 μmol / l, in animals of the experimental group, as well as a decrease in the level of liver enzymes and optimization of indicators of urological status. On the 30th day of the experiment, normalization of the bladder and kidney echograms was observed in the cats of the experimental group. Moreover, the dynamics of clinical changes in animals of the control group was characterized by a gradual weakening of signs of disorders of the hepatorenal system, starting from the 15th day of therapy, recovery occurred on the 30th day from the beginning of the course of pharmacocorrection, while in the control group the improvement was noted only on the 20th day, and recovery occurred only on the 45th day