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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vetpatol</journal-id><journal-title-group><journal-title xml:lang="ru">Ветеринарная патология</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Veterinary Pathology</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2949-4826</issn><publisher><publisher-name>Don State Technical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.23947/2949-4826-2026-25-1-34-40</article-id><article-id custom-type="edn" pub-id-type="custom">TSAVDS</article-id><article-id custom-type="elpub" pub-id-type="custom">vetpatol-2129</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПАТОЛОГИЯ ЖИВОТНЫХ, МОРФОЛОГИЯ, ФИЗИОЛОГИЯ, ФАРМАКОЛОГИЯ И ТОКСИКОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ANIMAL PATHOLOGY, MORPHOLOGY, PHYSIOLOGY, PHARMACOLOGY AND TOXICOLOGY</subject></subj-group></article-categories><title-group><article-title>Клинический случай пролиферативного и некротизирующего наружного отита (PNOE) у возрастной кошки</article-title><trans-title-group xml:lang="en"><trans-title>A Clinical Case of Proliferative and Necrotizing Otitis Externa (PNOE) in an Elderly Cat</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-7328-2890</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кочеткова</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Kochetkova</surname><given-names>Anastasia Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Анастасия Юрьевна Кочеткова, кандидат биологических наук, доцент кафедры «Биология и общая патология»,</p><p>344003, г. Ростов-на-Дону, пл. Гагарина, 1.</p><p>Web of Science ResearcherID: HKW-4687-2023.</p><p>Scopus ID: 60395624700.</p></bio><bio xml:lang="en"><p>Anastasia Yu. Kochetkova, Cand.Sci. (Biology), Associate Professor of the Biology and General Pathology Department, </p><p>1, Gagarin Sq., Rostov-on-Don, 344003.</p><p>Web of Science ResearcherID: HKW-4687-2023.</p><p>Scopus ID: 60395624700.</p></bio><email xlink:type="simple">lastik61@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4374-9244</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фомина</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Fomina</surname><given-names>Anna S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Анна Сергеевна Фомина, кандидат биологических наук, доцент кафедры «Биология и общая патология»,</p><p>344003, г. Ростов-на-Дону, пл. Гагарина, 1.</p><p>Web of Science ResearcherID: N-1772-2016.</p><p>Scopus ID: 55929829400.</p></bio><bio xml:lang="en"><p>Anna S. Fomina, Cand.Sci.(Biology), Associate Professor of the Biology and General Pathology Department,</p><p>1, Gagarin Sq., Rostov-on-Don, 344003. Russian Federation),</p><p>Web of Science ResearcherID: N-1772-2016.</p><p>Scopus ID: 55929829400.</p></bio><email xlink:type="simple">a_bogun@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Донской государственный технический университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Don State Technical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>08</day><month>05</month><year>2026</year></pub-date><volume>25</volume><issue>1</issue><fpage>34</fpage><lpage>40</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кочеткова А.Ю., Фомина А.С., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Кочеткова А.Ю., Фомина А.С.</copyright-holder><copyright-holder xml:lang="en">Kochetkova A.Y., Fomina A.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.vetpat.ru/jour/article/view/2129">https://www.vetpat.ru/jour/article/view/2129</self-uri><abstract><sec><title>Введение</title><p>Введение. Описан клинический случай пролиферативного и некротизирующего наружного отита (PNOE) у взрослой кошки — диагностика и лечение с применением такролимуса. Данный синдром неизвестной этиологии возникает у кошек в возрасте от 2 месяцев до 12 лет: билатерально поражается вогнутая часть ушной раковины и наружное слуховое отверстие; распространение заболевания по слуховому проходу сопровождается вторичными бактериальными или малассезиозными отитами. Рассмотрены 15 зарубежных исследований пролиферативного и некротизирующего наружного отита у кошек и собак, опубликованных в 2000–2025 гг.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В ноябре 2024 г. в ветеринарную клинику «Центр» (г. Ростов-на-Дону) обратились владельцы пятилетней кошки с жалобой на частые отиты у животного. Диагностика PNOE была основана на данных анамнеза, клинического осмотра, микроскопического и цитологического исследования содержимого ушного канала (ветеринарная лаборатория Vet Union, г. Москва). Терапия проводилась с применением 0,1% мази такролимуса наружно.</p></sec><sec><title>Результаты исследования</title><p>Результаты исследования. При осмотре на внутренней поверхности ушных раковин был обнаружен стеноз наружных слуховых проходов, значительное количество черных и сухих корочек. При посеве материала из слухового прохода на микрофлору выявлено вторичное микробное обсеменение (Pseudomonas aeruginosa, Klebsiella oxytoca и Enterobacter cloacae); при этом грибков рода Candidaspp и Malasseziaspp не выявлено. При микроскопическом анализе ушной серы клещей рода Otodectescynotis также не выявлено. После проведения терапии с применением 10 г 0,1% мази такролимуса наружно через 4 недели при отоскопическом исследовании ушных раковин отмечена нормализация состояния.</p></sec><sec><title>Обсуждение и заключение</title><p>Обсуждение и заключение. Доказана эффективность лечения PNOE у кошек с применением такролимуса наружно на корочки ушных раковин топикально. Представленные в статье данные и фотоматериалы могут быть полезными для практикующего ветеринарного врача при диагностике и лечении заболевания, регистрируемого достаточно редко.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. A clinical case of proliferative and necrotizing otitis externa (PNOE) in an elderly cat has been described, i.e. diagnostics and treatment with tacrolimus. This syndrome of unknown etiology occurs in cats aged from 2 months to 12 years. It bilaterally affects the concave pinnae and the external acoustic pore. Disease development in the ear canal is accompanied with the secondary bacterial or Malassezia otitides. Fifteen foreign works investigating PNOE in cats and dogs published in the period of 2000–2025 have been reviewed.</p></sec><sec><title>Materials and Methods</title><p>Materials and Methods. In November 2024, the owners of a five-year-old cat attended to the veterinary clinic “Center” (Rostov-on-Don) with the complaint on frequent otitides in their pet. PNOE diagnosis was based on the animal’s medical history, clinical examination, microscopic and cytological examination of discharge from ears (performed in the “Vet Union” veterinary laboratory, Moscow). Treatment included topical application of 0.1% tacrolimus ointment.</p></sec><sec><title>Results</title><p>Results. Examination of the inner surface of the auricles revealed stenosis of the external ear canals and a significant number of black, dry crusts. An ear culture test revealed secondary microbial contamination with Pseudomonas aeruginosa, Klebsiella oxytoca, and Enterobacter cloacae; whereas, Candida or Malassezia spp fungi were not isolated. Also, during microscopy of earwax, no mites of the genus Otodectescynotis were isolated. After 4 weeks of treatment with 10 g of 0.1% tacrolimus ointment applied topically, normalization of condition was noticed during the otoscopic examination of the auricles.</p><p>Discussion and Conclusion. The efficiency of treating PNOE in cats with tacrolimus ointment applied topically to the auricle crusts has been proved. The data and photographs presented in the article may be useful for practicing veterinarians for diagnostics and treatment of this relatively rare disease.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>клинический случай</kwd><kwd>кошки</kwd><kwd>пролиферативный и некротизирующий наружный отит</kwd><kwd>PNOE</kwd><kwd>такролимус</kwd></kwd-group><kwd-group xml:lang="en"><kwd>clinical case</kwd><kwd>cats</kwd><kwd>proliferative and necrotizing otitis externa</kwd><kwd>PNOE</kwd><kwd>tacrolimus</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Mauldin EA, Ness TA, Goldschmidt MH. Proliferative and Necrotizing Otitis Externa in Four Cats. Veterinary Dermatology. 2007;18(5):370–377. https://doi.org/10.1111/j.1365-3164.2007.00614.x</mixed-citation><mixed-citation xml:lang="en">Mauldin EA, Ness TA, Goldschmidt MH. 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