vetpatolВетеринарная патологияRussian Journal of Veterinary Pathology2949-4826Don State Technical Universityvetpatol-265Research ArticleБОЛЕЗНИ ПЧЕЛПЕРСПЕКТИВЫ ИСПОЛЬЗОВАНИЯ ОНКОМАРКЕРОВ В ВЕТЕРИНАРНОЙ ОНКОЛОГИИPERSPECTIVE OF USING OF TUMOR MARKERS IN VETERINARY ONCOLOGYВакуленкоМайяVakoulenkoMaiaNikdentella-22@yandex.ruЮФУRussian Federation201620122016042329Copyright © Вакуленко .М., 20162016Вакуленко .М.Вакуленко .М.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.vetpat.ru/jour/article/view/265

В обзоре представлены сведения о некоторых аспектах экологии возбудителя холеры. Холерные вибрионы вместе с другими представителями флоры и фауны заселяют морские и речные водоемы, как экваториальных стран, так и северных - вплоть до Ледовитого океана. Обсуждается связь холерных вибрионов со всеми компонентами водной гидробиоты. В поясах умеренного климата, так же как и на эндемичных по холере территориях, представители зоо- и фитопланктона являются одной из экологических ниш для холерных вибрионов, в том числе в зимний период, и могут служить факторами персистенции этих микроорганизмов во внешней среде, формируя возможные вторичные очаги при заносе возбудителя

Data on some tumor markers studied in mammary gland cancer in dogs and cats are given. The purpose of the article was to analyze the use of tumor markers in veterinary medicine. It can be assumed that the expression of PCNA, Ki67, IGF, VRCA1 and BRCA2 genes may be useful parameter for the diagnosis and monitoring of mammary gland cancer in dogs, and ERBB2 expression, VRCA1 and BRCA2 - in cats. But proto-oncogenes ERBB2 and SATB1 in dogs did not show increasing expression of in cancerous tumors and can not be used in veterinary oncology, as they are used in human one. Also does not fit for use as a tumor the marker protein P53 as it reflects the degree of DNA damage that may be caused by various factors and does not necessarily result to carcinogenesis. Estrogen receptor activity also can not be used, since in increase in tumor malignancy grows resistance to proliferative stimulation. In conclusion, it can be assumed that the study of the activity of genes responsible for DNA repair (CADD45, RAD17, RAD21, RPD21, RPA, SMC1A and TOPBP1), can be promising, as in human cancer have been identified mutations leading to DNA repair violation and the emergence of cancer already. It remains to reveal similar mutations in dog and cat genome.

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The authors declare that there are no conflicts of interest present.