We studied the immunobiological properties of the associated vaccine against myxomatosis, pasteurellosis and rabbits hemorrhagic disease types 1 and 2, which consists of two components. Liquid component - antigens of inactivated hemorrhagic disease virus (RGDV-I and -II) and antigen of inactivated pasteurellosis bacteria (P. multocida serotype A), in the form of a mixture on a solution of aluminum hydroxide gel. The dry component is the attenuated rabbit myxomatosis virus (strain «Mixo / ARRIAH-18»). Before use, the components were mixed in predetermined proportions and inoculated intramuscularly in rabbits. The reactogenic, antigenic and protective effects of the combined preparation were evaluated. The following is defened. Тhe reactogenic effect of the drug in the form of a local inflammatory reaction can persist up to 12 days after injection. The accumulation of serum antibodies to a stable protective level to all antigenic components occurs 14 days after immunization. The maximum level of protection for positive control to the virus of hemorrhagic disease types I and II, completely protective level of immunity to pasteurellosis and index of protection against myxomatosis, exceeding three orders of magnitude the drug is able to create to a 28 days after vaccination. An important advantage of the associated vaccine over the known commercial analogs is the possibility of using the drug as a single intramuscular injection, without resorting to multiple vaccinations of animals against each disease, reducing labor costs and stress of animals.