In the practice of treating small domestic animals, cardiac diseases account for a signifcant part of cases of internal diseases of non-infectious etiology. Te development of new directions in this area of veterinary medicine continues at the present time. Te incidence of dilated cardiomyopathy in dogs - leading to a reduction in the life of those who come to the clinic is 30% or more. Te article provides a clinical assessment (in a comparative aspect) of the therapeutic efcacy of treatment of dilated cardiomyopathy in dogs with the use of cardiac glycoside, angiotensin-converting enzyme (ACE) and diuretics. An assessment of their infuence on improving the quality of life of animals is given - the disappearance or decrease in the manifestation of clinical signs of the disease in 3 months. As a result of the experiment, in the treatment of dilated cardiomyopathy with only digoxin, symptoms such as cough, shortness of breath, they decline only afer 1 month of treatment. In the second group, where the treatment was carried out with digoxin and an angiotensin-converting enzyme inhibitor - enalapril, the patients' quality of life improved already in the frst 15 days. Te authors found that as a result of the treatment of dilated cardiomyopathy with atrial arrhythmia, the survival rate is higher than with ventricular arrhythmia.