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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vetpatol</journal-id><journal-title-group><journal-title xml:lang="ru">Ветеринарная патология</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Veterinary Pathology</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2949-4826</issn><publisher><publisher-name>Don State Technical University</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">vetpatol-640</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКУШЕРСТВО</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OBSTETRICS</subject></subj-group></article-categories><title-group><article-title>РОЛЬ ESCHERICHIA COLI В РАЗВИТИИ ПИОМЕТРЫ У СОБАК</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ермакова</surname><given-names>И. А.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карташов</surname><given-names>С. Н.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Корниенко</surname><given-names>Г. Г.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Василенко</surname><given-names>В. Н.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ключников</surname><given-names>А. Г.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ГНУ СКЗНИВИ Россельхозакадемии</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>20</day><month>12</month><year>2012</year></pub-date><volume>0</volume><issue>4</issue><fpage>16</fpage><lpage>20</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ермакова И.А., Карташов С.Н., Корниенко Г.Г., Василенко В.Н., Ключников А.Г., 2012</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="ru">Ермакова И.А., Карташов С.Н., Корниенко Г.Г., Василенко В.Н., Ключников А.Г.</copyright-holder><copyright-holder xml:lang="en">Ермакова И.А., Карташов С.Н., Корниенко Г.Г., Василенко В.Н., Ключников А.Г.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.vetpat.ru/jour/article/view/640">https://www.vetpat.ru/jour/article/view/640</self-uri><abstract><p>На сегодняшний день пиометра, или гнойный эндометрит, по причине смертности у сук стоит на втором месте после онкологических заболеваний. Целью данного исследования было выяснить факторы патогенности Escherichia coli, выделенной из матки у собак больных пиометрой и определить возможные риски для человека, связанные с эшерихиозом. В процессе исследования были выявлены факторы патогенности различных штаммов E. coli, выделенных от 100 собак с пиометрой. Исследовали внутриматочное содержимое собак, больных пиометрой. Штаммы E. coli идентифицировали посредством ПЦР-диагностики. Кроме того, подсчитывали количество колониеобразующих единиц, а также были сделаны тесты на антибактериальную чувствительность изолированных штаммов E. сoli. Из всех выделенных микроорганизмов E. coli составила 76,6 %. При этом 120 штаммов E. coli (79,5 %) были положительны на ген sfa, 86 штаммов (56,9 %) были положительны на ген cnf, 87 штаммов (57,6 %) были положительны на ген pap, 52 штаммов (34, 4 %) были положительны для hly, 51 штаммов (33,8 %) были положительны для iuc и 5 штаммов (3.3 %) были положительны для afa генов. Исследование также показало наибольшую чувствительность выделенных штаммов E. coli к норфлоксацину, полимиксину B, сульфазотрину, хлоранфениколу и энрофлоксацину. Факторы патогенности E. coli были идентифицированы в 98,0 % изученных штаммов, демонстрируя высокую частоту потенциально патогенных микроорганизмов.</p></abstract><trans-abstract xml:lang="en"><p>E. coli was the most widespread a microorganism allocated from dogs with pyometra (76,6 %). 120 strains E. coli (79,5 %) were positive on a gene sfa, 86 (56,9 %) were positive on a gene cnf, 87 (57,6 %) were positive on a gene pap, 52 (34, 4 %) were positive for hly, 51 (33,8 %) were positive for iuc and 5 (3,3 %) were positive for afa genes. One observed more sensitivity of E. coli to norfloxacin, polimixin B, sulphazotrin, chloranfenicol and enrofloxacin. In 42% of the samples of uterine walls where microorganisms were isolated, the sizes of the areas of the inflammatory responses corresponded to 39-56%. Factors of pathogenicity E. Coli have been identified in 98,0 % studied strains, showing high frequency potentially pathogenic E. coli. Probably, that the dogs, living glad with the man not one thousand years are the important factor in transfer pathogenic E. coli to other animals and the man. Keywords: dogs, Escherichia coli, pyometra, endometritis, diagnostics.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>собаки</kwd><kwd>Escherichia coli</kwd><kwd>пиометра</kwd><kwd>эндометрит</kwd><kwd>диагностика</kwd><kwd>dogs</kwd><kwd>Escherichia coli</kwd><kwd>pyometra</kwd><kwd>endometritis</kwd><kwd>diagnostics</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Beutin, L. (1999): Escherichia coli as a pathogen in dogs and cats. Vet. Res., 30, 285-298.</mixed-citation><mixed-citation xml:lang="en">Beutin, L. (1999): Escherichia coli as a pathogen in dogs and cats. Vet. 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