Echinococcosis in the regions of the North Caucasus occurs in more than 30 mouse-like rodents with the formation of synanthropic foci of invasion. e aim of this work is to study echinococcosis of rodents as an epizootic and epidemiological risk in the biosphere (specially protected) territories of the North Caucasus region. e authors studied the dynamics of the formation of synanthropic foci of echinococcosis, representing an epidemiological threat, in the specially protected territories of Karachay-Cherkessia and the Elbrus - Kabardino-Balkaria. It was found that in the mountain-resort areas of Arkhyz, Teberda and Dombai, indicators of the invasion extensiveness of cystic echinococcosis in nine species of mouse rodents are su cient for the formation of persistent trouble in synanthropic di use foci of zoonotic disease. e incidence indices of cystic echinococcosis in rodents of nine species in specially protected resort areas of Kabardino-Balkaria (Cheget, Azau, Dzhantugan) in 2018-2020 were comparatively more than in Arkhyz, Teberda and Dombai, which in generally is according to the complete disregard for planned deratization measures in relation to zoonosis. e formation of synanthropic foci of zoonose in the specially protected resort territories of Arkhyz, Teberda, Dombay (Karachay-Cherkess Republic) and Cheget, Azau, Jantugan (Kabardino-Balkarian Republic) can lead to an increase in echinococcosis of carnivores and to contamination of the soils of the resort and recreational complex with eggs of the cestode Echinococcus granulosus.