Presence of an insuficiently high level of veterinary and sanitary indicators of animal husbandry on fragmented farms has led to an increase in infectious and invasive diseases. The aim of the study was to study the clinical state of the animal's body and changes in hematological parameters before use and after treatment of sarcoptoidosis in cattle. The experiment was carried out on bulls and heifers aged from 6 to 10 months with an average body condition and live weight from 100 to 120 kg. The experimental animals were divided into three groups: two experimental and one control, 15 animals each. Before the experiment and 7, 14 and 21 days after treatment with acaricidal preparations, scrapings of the affected skin and blood were taken from animals of all groups for research. The animals of the first experimental group were injected subcutaneously with ivermectin in the forearm at a dose of 5 ml per head, and in the second experimental group, cidectin was injected subcutaneously at a dose of 5 ml per animal in the forearm. The animals of the control group were not treated. According to the results of the conducted hematological studies, a decrease in the number of erythrocytes and hemoglobin in sarcoptoidosis was found. All this indicates a decrease in the supply of oxygen to the body, and therefore to organs and tissues. A noticeable decrease in the number of monocytes and lymphocytes was observed in the leukocyte formula