The aim of the study was to determine the effectiveness of a new antiseptic preparation for veterinary purposes «Smake-HUVS» to prevent diseases of the hoofs of cattle. The authors present studies of the use of the antiseptic preparation «Smake-HUVS» in the form of an aqueous solution in 2 and 5 % concentrations. On the basis of the results of the study in the conditions of the farm, it was determined that the clinical signs in the diseased animals treated with the studied drug «Smake-HUVS» were significantly less pronounced in comparison with the control group. Also, as shown by the research results, the antiseptic preparation «Smake-HUVS» was the most effective in comparison with the 10 % formalin solution in the experimental group treated according to the traditional farming method. The data obtained allow us to conclude that the optimal concentration of the drug «Smake-HUVS» for preventive measures is a 2 % aqueous solution of the drug, used twice in the morning and in the evening for 30 days, or a 5 % aqueous solution of the drug «Smake-HUVS», used twice in the morning and in the evening for 7 days in the form of hoof baths.