Parasitoses are widespread in ruminants. Among other pathologies in the conditions of the Caspian lowland, where helminthiases dominate. Their cause 63 types of pathogens, among which fascioliasis, dicroceliasis, echinococcosis, monieziosis and strongylatoses are often recorded. Almost always, helminthiases occur in mixed invasions, the invasion extensiveness (EI) reaches 84.0 %, with an invasion intensity (II) of 5-3240 ind. A feature of the epizootology of animal helminthiases in the territory of the Caspian Lowland is the duration of the warm period of the year up to 210-220 days, when + (10-12) °С is often observed in December and January, and the active state of the invasive stage of pathogens in the external environment and infection associated with this livestock. With intense damage to organs (liver, lungs, intestines), sick animals experience large «parasitic loads», often with irreversible pathological changes that are incompatible with life. Often in mixed invasions, from 4 to 17 types of pathogens are recorded. In the region, a hard epizootic situation is created annually for the most dangerous helminthiases, which cause great damage to livestock. Powerful stably functioning foci have formed in biotopes, which are constantly are seeded with an invasive beginning through the source of invasion (infected animals) throughout the year. Therefore, it is necessary at the end of summer and autumn to carry out diagnostic studies on helminthiases of animals by lifetime coprological, postmortem autopsies of sick cattle. In October, to conduct planned coprological research of 10 % of the livestock for helminthiases and preventive deworming of all animals with broad-spectrum dosage forms. In addition, it is necessary to carry out pasture prevention and land reclamation throughout the year