PERSPECTIVE OF USING OF TUMOR MARKERS IN VETERINARY ONCOLOGY
Abstract
Data on some tumor markers studied in mammary gland cancer in dogs and cats are given. The purpose of the article was to analyze the use of tumor markers in veterinary medicine. It can be assumed that the expression of PCNA, Ki67, IGF, VRCA1 and BRCA2 genes may be useful parameter for the diagnosis and monitoring of mammary gland cancer in dogs, and ERBB2 expression, VRCA1 and BRCA2 - in cats. But proto-oncogenes ERBB2 and SATB1 in dogs did not show increasing expression of in cancerous tumors and can not be used in veterinary oncology, as they are used in human one. Also does not fit for use as a tumor the marker protein P53 as it reflects the degree of DNA damage that may be caused by various factors and does not necessarily result to carcinogenesis. Estrogen receptor activity also can not be used, since in increase in tumor malignancy grows resistance to proliferative stimulation. In conclusion, it can be assumed that the study of the activity of genes responsible for DNA repair (CADD45, RAD17, RAD21, RPD21, RPA, SMC1A and TOPBP1), can be promising, as in human cancer have been identified mutations leading to DNA repair violation and the emergence of cancer already. It remains to reveal similar mutations in dog and cat genome.
References
1. Santos S. Sequence Variants and Haplotype Analysis of Cat ERBB2 Gene A Survey on Spontaneous Cat Mammary Neoplastic and Non - Neoplastic Lesions / S. Santos, E. Bastos, C. S. Baptista, D. Sa, C. Caloustian, H. Guedes-Pinto, F. Gärtner, I. V. Gut, R. Chaves // International Journal of Molecular Sciences. - 2012. - № 13. - P. 2783-2800.
2. Santos S. ERBB2 in Cat Mammary Neoplasisas Disclosed a Positive Correlation between RNA and Protein Low Expression Levels A Model for erbB 2 Negative Human Breast cancer / S. Santos, C. S. Baptista, M.V. Abreu Rui, E. Bastos, I. Amorim, I. G. Gut, F. Gärtner, R. Chaves // PLos ONE - 2013. - № 8 (12). - e83673.
3. Klopfleisch R. Molecular Carcinogenesis of Canine Mammary Tumors News From an Old Disease / R. Klopfleisch, H. von Euler, G. Sarli, S. S. Pinho, F. Gärtner, A. D. Gruber // Veterinary Pathology. - 2011. - № 48 (1). - P. 98-116.
4. Фатех-Могхадам А. Рациональное использование опухолевых маркеров / A. Фатех-Могхадам, П. Стиебер // - M: Roche-Diagnostics, 1993. - 54 с.
5. Пальцева М. А. Системы генетических и эпигенетических маркеров в диагностике онкологических заболеваний / М. А. Пальцева, Д. В. Залетаева // - M: Медицина, 2009. - 384с.
6. He X. Proliferating cell nuclear antigen destabilizes c-Abl tyrosine kinase and regulates cell apoptosis in response to DNA damage. / X. He, C. Wei, T. Song, J. Yuan, Y. Zhang, Q. Ma, W. Shi, H. Zhong // Apoptosis. - 2009. - № 14. - P. 268-275.
7. Moldovan G. L. PCNA, the maestro of the replication fork / G. L. Moldovan, B. Pfander, S. Jentsch // Cell. - 2007. - № 129. - P. 665-679.
8. Gerdes J. Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation / J. Gerdes, U. Schwab, H. Lemke, and H. Stein // Int. J. Cancer. - 1983. - № 31. - P. 13-20.
9. Yerushalmi R. Ki67 in breast cancer: prognostic and predictive potential / R. Yerushalmi, R. Woods, P. M. Ravdin, M. M. Hayes, K. A. Gelmon // Lancet Oncol. - 2010. - № 11. - P. 174-183.
10. Zacchetti A. Validation of the use of proliferation markers in canine neoplastic and non-neoplastic tissues: comparison of KI-67 and proliferating cell nuclear antigen (PCNA) expression versus in vivo bromodeoxyuridine labelling by immunohistochemistry / A. Zacchetti, E. van Garderen, E. Teske, H. Nederbragt, J. H. Dierendonck, G. R. Rutteman // APMIS. - 2003 - № 111. - P. 430-438.
11. Geraldes M. Immunohistochemical study of hormonal receptors and cell proliferation in normal canine mammary glands and spontaneous mammary tumours / M. Geraldes, F. Gartner, F. Schmitt // Vet. Rec, - 2000. - № 146. - P. 403-406.
12. Löhr C. V. Characterization of the proliferation state in canine mammary tumors by the standardized AgNOR method with postfixation and immunohistologic detection of Ki-67 and PCNA / C. V. Löhr, J. P. Teifke, K. Failing, E. Weiss // Veterinary Pathology. - 1997. - № 34. - P. 212-221
13. Penã L. L. Immunohistochemical detection of Ki-67 and PCNA in canine mammary tumors: relationship to clinical and pathologic variables / L. L. Penã, A. I. Nieto, D. Perez-Alenza, P. Cuesta, M. Castaño // J. Vet. Diagn. Invest. - 1998. - № 10. - P. 237-246.
14. Preziosi R. Detection of proliferating cell nuclear antigen (PCNA) in canine and feline mammary tumours / R. Preziosi, G. Sarli, C. Benazzi, P. S. Marcato // J. Comp. Pathol. - 1995. - № 113. - P. 301313.
15. Sarli G. Prognostic value of histologic stage and proliferative activity in canine malignant mammary tumors / G. Sarli, R. Preziosi, C. Benazzi, P. S. Marcato // J. Vet. Diagn. Invest. - 2002. - № 14. - P. 25-34.
16. Murakami Y. Immunohistochemical analysis of cyclin A, cyclin D1 and P53 in mammary tumors, squamous cell carcinomas and basal cell tumors of dogs and cats / Y. Murakami, S. Tateyama, A. Rungsipipat, K. Uchida, R. Yamaguchi // J. Vet. Med. Sci. - 2000. - № 62. - P. 743-750.
17. Klopfleisch R. The combined expression pattern of BMP2, LTBP4, and DERL1 discriminates malignant from benign canine mammary tumors / R. Klopfleisch, P. Klose, A. D. Gruber // Veterinary Pathology. - 2010. - № 47. - P. 446-454.
18. Ferretti G. HER2/neu role in breast cancer: from a prognostic foe to a predictive friend / G. Ferretti, A. Felici, P. Papaldo, A. Fabi, F. Cognetti // Curr Opin Obstet Gynecol. - 2007. - № 19. - P. 56-62.
19. Gama A. Identification of molecular phenotypes in canine mammary carcinomas with clinical implications: application of the human classification / A. Gama, A. Alves, F. Schmitt // Virchows Arch. - 2008. - № 453. - P. 123-132.
20. Hsu W. L. Increased survival in dogs with malignant mammary tumours overexpressing HER-2 protein and detection of a silent single nucleotide polymorphism in the canine HER-2 gene / W. L. Hsu, H. M. Huang, J. W. Liao, M. L. Wong, S. C. Chang // Vet. J. - 2009. - № 180. - P. 116-123.
21. Gama A. Immunohistochemical expression of epidermal growth factor receptor (EGFR) in canine mammary tissues / A. Gama, F. Gartner, A. Alves, F. Schmitt // Res. Vet. Sci. - 2009. - № 87. - P 432-437.
22. Werner H. The insulin-like growth factor-I receptor as an oncogene / H. Werner, I. Bruchim // Arch Physiol. Biochem. - 2009. - № 115. - P. 58-71.
23. Mol J. A. Mammary growth hormone and tumorigenesis: lessons from the dog / J. A. Mol, I. S. Lantinga-van Leeuwen, E. van Garderen, P. J. Selman, M. A. Oosterlaken-Dijksterhuis, J. A. Schalken, A. Rijnberk // Vet. Q. - 1999. - № 21. P. 111-115.
24. Mol J. A. The role of progestins, insulin-like growth factor (IGF) and IGF-binding proteins in the normal and neoplastic mammary gland of the bitch: a review / J. A. Mol, P.J . Selman, E. P. Sprang, J. W. van Neck, M. A. Oosterlaken-Dijksterhuis // J. Reprod Fertil. Suppl. - 1997. - № 51. - P. 339-344
25. Queiroga F. L. Crosstalk between GH/IGF-I axis and steroid hormones (progesterone, 17beta-estradiol) in canine mammary tumours / F. L. Queiroga, M. D. Perez-Alenza, G. Silvan, L. Peña, C. S. Lopes, J. C. Illera // J. Steroid Biochem. Mol Biol. - 2008. - № 110. - P. 76-82.
26. Schneider R. Factor’s influencing canine mammary cancer development and postsurgical survival / R. Schneider, C. R. Dorn, D. O. Taylor // J. Natl. Cancer Inst. - 1969. - № 43. - P. 1249-1261.
27. Sorenmo K. U. Effect of spaying and timing of spaying on survival of dogs with mammary carcinoma / K. U. Sorenmo, F. S. Shofer, M. H. Goldschmidt // J. Vet. Intern Med. - 2000. - № 14. - P. 266-270.
28. Chang C. C. Evaluation of hormone receptor expression for use in predicting survival of female dogs with malignant mammary gland tumors / C. C. Chang, M. H. Tsai, J. W. Liao, J. P. Chan, M. L. Wong, S. C. Chang // J. Am. Vet. Med. Assoc. - 2009. - № 235. - P. 391-396.
29. De Las Mulas J. M. A prospective analysis of immunohistochemically determined estrogen receptor alpha and progesterone receptor expression and host and tumor factors as predictors of diseasefree period in mammary tumors of the dog / J. M. de Las Mulas, Y. Millan, R. Dios // Veterinary Pathology. - 2005. - № 42. - P. 200-212.
30. Millanta F. Comparison of steroid receptor expression in normal, dysplastic, and neoplastic canine and feline mammary tissues / F. Millanta, M. Calandrella, G. Bari, M. Niccolini, I. Vannozzi, A. Poli // Res. Vet. Sci. - 2005. - № 79. - P. 225-232.
31. Martin P. M. Animal models for hormone-dependent human breast cancer: relationship between steroid receptor profiles in canine and feline mammary tumors and survival rate / P. M. Martin, M. Cotard, J. P. Mialot, and F. André, J. P. Raynaud // Cancer Chemother Pharmacol. - 1984. - № 12. - P. 13-17.
32. Klopfleisch R. Increased expression of BRCA2 and RAD51 in lymph node metastases of canine mammary adenocarcinomas / R. Klopfleisch, A. D. Gruber // Veterinary Pathology. - 2009. - № 46. - P. 416-422.
33. Rivera P. Mammary tumor development in dogs is associated with BRCA1 and BRCA2 / P. Rivera, M. Melin, T. Biagi, T. Fall, J. Häggström, K. Lindblad-Toh, H. von Euler // Cancer Res. - 2009. - № 69. - P. 87708774
34. Yoshikawa Y. Reduced canine BRCA2 expression levels in mammary gland tumors / Y. Yoshikawa, M. Morimatsu, K. Ochiai, T. Ishiguro-Oonuma, S. Wada, K. Orino, K. Watanabe // BMC Vet. Res. - 2015. - № 23. - P. 11-159.
35. Klopfleisch R. Metastatic canine mammary carcinomas can be identified by a gene expression profile that partly overlaps with human breast cancer profiles / R. Klopfleisch, D. Lenze, M. Hummel et al. // BMC Cancer, 2010. 10.618.
Review
For citations:
Vakoulenko M. PERSPECTIVE OF USING OF TUMOR MARKERS IN VETERINARY ONCOLOGY. Russian Journal of Veterinary Pathology. 2016;(4):23-29. (In Russ.)
Views:
143
Email this article 