THE DYNAMICS OF ONCOGENESIS UNDER PAPILLOMATOSIS

Abstract

This work deals with the histological features of the oncogenesis of tumors with disseminated papillomatosis large horns of cattle at the tissue and cellular levels. On the basis of clinical and histological studies are carried out conditional typing papillomas of cattle identified histomorphometric indices depending on the type of papillomas using such indicators, as the core area and the cells of banalities and Kolotilov, parenchymal-stromal and nuclear-cytoplasmic ratio. Specified differential criteria to determine the nature of the growth of papillomas and the stage of progression. Noted, that the morphological changes in oncoprogresso accompanied by changes in the density and size of tumors, activation of fibroblastic cells forming the stroma of a number of papillae, strengthening of the signs of parakeratosis and hyperkeratosis of the surface of the tumor, an increase in the mass of connective tissue and a correspondingly increased area of the surrounding parenchyma of the tumor. It is established that the size of koilocytes vary depending on the type of warts that determines the dynamics of the cancer process. Morphometric data of koilocytes, detectable in histological examination showed changes in the area of cells and area change kernels. Increasing the area of cells on 55,43 % and 104,4 %, respectively, with the increase in the area of the nucleus of koilocytes by 5,24 % and of 20,97 % relative performance of core koilocytes papillomas of the first type, allow to assert about increase koilocytes due to changes in nuclear-cytoplasmic ratio toward the cytoplasm.