THERAPEUTIC EFFICACY OF CERTAIN PREPARATIONS IN HEPATOPATHY TREATMENT IN DOGS

Abstract

The paper reports results of comparative analysis of Geptral 24.6 mg/kg, Lipoton 5 mg/kg, and Gamavit 0.5 mg/ kg in treatment of chronic hepatopathy in dogs. The goal was to conduct comparative study of hepatoprotective properties of the preparations. The experiment enrolled 30 dogs with chronic liver injury manifestations proved by biochemical blood serum analysis. Pharmacological activity of the test drugs was evaluated through clinical examination of the animals, and evaluation of the blood serum biochemical properties representative for liver functions. Test preparations were introduced intramuscularly once a day for one week. The treatment resulted in apparent improvement of liver functions proved by changes in the blood biochemical analysis. Total blood protein raised by 28.6% in Geptral, by 30.7% in Lipoton, and by 29% in Gamavit therapy groups against pre-treatment level. Bilirubin content before treatment was 6.3 ± 0.18 mmol/l as a result of either excessive production or ineffective conjugation in the liver. Following the treatment the value decreased by 20.6% (Lipoton), 19% (Geptral), and 15.8% (Gamavit). This may indicate restoration of pigment metabolism functions in liver. Blood ALT and AAT levels were elevated (84.2 IU/l and 72.8 IU/l respectively) before the treatment. Geptral was the most effective in decreasing content of the enzymes (AAT decrease by 1.7 times, ALT decrease by 1.7 times as compared with pre-treatment values). ALT and AST intracellular enzymes occur in small amount in the blood of healthy animals, and their elevation indicates cell lysis. The study proves efficacy of Lipoton and Gamavit preparations, and validates their use in hepatopathy therapy in dogs.