STUDY OF TOLERANCE OF THE ANTICOCCIDIA DRUG OF DECVICOX ON THE BROILERS CHICKEN

The main method for the successful prevention and treatment of chicken eimeriosis is the development of new highly effective anticoccidia drugs. It is known that the toxicological characteristics of drugs is very important in the choice of the drug. In this regard, knowledge of toxicity parameters is necessary for its introduction into the market. This article describes the toxicological characteristics of the new anticoccidic drug Decvicox in broilers. The studies were carried out in vivarium conditions in All-Russian Research Institute fundamental and applied parasitology of plants and animals named after K. I. Skryabin during the period from July to September 2017 on healthy broilers of the Cobb 500 cross. The birds were kept in a group method in two-tier birdcages (5 animals each). Before the start of the experiment, the chickens were divided into 4 similar groups (3 experimental and 1 control of 15 goals, respectively). The subchronic toxicity of the drug Decvicox was evaluated in accordance with the guidelines for the experimental (preclinical) study of new pharmacological substances. The chickens of the experimental groups were given the drug in a group way with water for drinking for 60 days at a therapeutic dose, as well as three and five times higher doses. Toxicological properties were evaluated by the dynamics of changes in bird body weight, as well as on the basis of morphological and biochemical blood tests in comparison with individuals who did not receive drugs. As a result of studies, it was found that the use of the drug in therapeutic, three- and five times therapeutic doses for 60 days does not cause clinical changes in the condition of chickens. In all groups treated with the drug, no deviations of body weight were detected in comparison with the control group. The clinical status data are confirmed by hematological studies, which indicate that prolonged use of the drug Decvicox does not adversely effect on the morphological and biochemical parameters of the bird.

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