APPLICATION OF CELL THERAPY ON THE EXAMPLE OF INDUCED SUGAR DIABETES USING AN UNDIVIDED BONE MARROW STEM CELL POPULATION
https://doi.org/10.25690/VETPAT.2020.1.71.013
Abstract
A study on the use of cell therapy using an undivided population of bone marrow cells as a therapy for streptozotocin-induced diabetes mellitus in mice line C57Bl/6 was conducted from 2013 to 2014. We presented the results of the assessment of migration activity, engraftment, and distribution of an undivided bone marrow stem cell population in the body of female mice recipient line C57Bl/6 with streptozotocin-induced diabetes mellitus (type 1). Using polymerase chain reaction, the migration and distribution of donor cells in the organs of female recipients were studied. To identify the accumulation and distribution of transplanted donor GFP cells, a histological examination was performed. It was shown that an undivided population of bone marrow stem cells not only migrates and is distributed in the affected area, but also affects its regeneration. As a result, this therapeutic approach can become the basis for the development of methods and methods of cell therapy in regenerative medicine and veterinary medicine. This can further contribute to the development of new technologies and tools for the treatment and maintenance of patients with severe pathology, not only in veterinary medicine, but also in human medicine.
About the Authors
T. V. Miller
Southern Federal University (SRTC Neurotechnology SFU)
Russian Federation
Russian Federation
G. V. Karantysh
Southern Federal University (SRTC Neurotechnology SFU)
Russian Federation
Russian Federation
A. N. Vovk
Southern Federal University (SRTC Neurotechnology SFU)
Russian Federation
Russian Federation
L. D. Safronova
(FSBEI) of higher education (HE) «Don State Technical University»
Russian Federation
Russian Federation
A. M. Ermakov
(FSBEI) of higher education (HE) «Don State Technical University»
Russian Federation
Russian Federation
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Review
For citations:
Miller T.V., Karantysh G.V., Vovk A.N., Safronova L.D., Ermakov A.M. APPLICATION OF CELL THERAPY ON THE EXAMPLE OF INDUCED SUGAR DIABETES USING AN UNDIVIDED BONE MARROW STEM CELL POPULATION. Russian Journal of Veterinary Pathology. 2020;(1):57-67. (In Russ.) https://doi.org/10.25690/VETPAT.2020.1.71.013
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