ЭФФЕКТ ВНУТРИБРЮЩИННО ВВЕДЕННОГО БОГАТОГО ПРОЛИНОМ ПОЛИПЕПТИДА НА АКТИВНОСТЬ ИЗОФОРМ ЦИТОХРОМА b558 ТКАНЕЙ БЕЛЫХ КРЫС
Abstract
The changes of the level and activity of new isoforms of cytochrome b558 in tissues including in immune protection and in erythrocytes membranes of the rats under the influence of intraperitoneally injected proline-rich polypeptide
The mechanisms of influence of the intraperitoneal injection of rats by proline-reach polypeptide (PRP-1) three times to 10 mkg during 10 days on the state of prooxidarive activity metalloproteins in vivo are connected with the decrease of NADPH-depending superoxide-producing and increase of methemoglobin (metHb)-reducing activities of new isoforms of cytochrome (cyt) bS58HI from erythrocytes membranes (EM) and fraction of cyt. b558 from cells membranes (CM) of the tissues, including in immune protection (bone marrow, spleen, thymus). It is supposed, that these effects of PRP-1 are connected with the chelation of HO-radicals, and the «elevation» of the level of endogenous proline-rich polypeptide in the content of the cyt b558 molecule, as a receptor of exogenous PRP-1.
Thus, the metHb-reducing activity characterized cyt b558 of above indicated CM tissues, which is testified about the including of erythrocytes in immune protection, which is connected with the oxygen homeostasis.
The mechanisms of influence of the intraperitoneal injection of rats by proline-reach polypeptide (PRP-1) three times to 10 mkg during 10 days on the state of prooxidarive activity metalloproteins in vivo are connected with the decrease of NADPH-depending superoxide-producing and increase of methemoglobin (metHb)-reducing activities of new isoforms of cytochrome (cyt) bS58HI from erythrocytes membranes (EM) and fraction of cyt. b558 from cells membranes (CM) of the tissues, including in immune protection (bone marrow, spleen, thymus). It is supposed, that these effects of PRP-1 are connected with the chelation of HO-radicals, and the «elevation» of the level of endogenous proline-rich polypeptide in the content of the cyt b558 molecule, as a receptor of exogenous PRP-1.
Thus, the metHb-reducing activity characterized cyt b558 of above indicated CM tissues, which is testified about the including of erythrocytes in immune protection, which is connected with the oxygen homeostasis.
About the Authors
Г. Агамян
Институт биохимии им. Г. Бунятяна НАН РА
Russian Federation
Russian Federation
Р. Симонян
Russian Federation
А. Арутюнян
Russian Federation
Г. Симонян
Russian Federation
М. Симонян
Russian Federation
А. Галоян
Russian Federation
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Review
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