ANTHELMINTIC DRUGS EFFICACY AGAINST BOVINE FASCIOLIASIS

Abstract

Parasitic diseases in cattle are widespread in the territory of the Russian Federation. At the farms of Udmurtia various kinds of ruminants parasitic fauna are represented and therefore the vast use of antiparasitic drugs entails a range of problems: their toxic side effects on animals’ organism, restrictions for livestock products consumption (milk, meat). Based on the aforementioned, the aim of the work was to determine the therapeutic efficacy of anthelmintic drugs against bovine fascioliasis under the Udmurt Republic conditions. The coprological examinations were made in the conventional sedimentation technique; in total 50 head of cows aged 3–5 years were examined. To determine the extensive and intensive efficacy of the drugs based on the analogy principle five groups per 10 animals were formed, four - experimental ones and the fifth served as a control one. Four drugs were used in the experiment: «Rolenol», «Santel 10 %», «Albendozole 10 %» (suspension for oral administration) and «Santomectin». When evaluating the efficacy of anthelmintic drugs against trematode infestations in cattle it was found that all of the used drugs showed high efficacy on the 40th day after dehelmintization, but due to the fact that the causative agent Fasciola hepatica belongs to biohelminthic diseases with chronic course the period of therapeutic efficacy was evaluated for up to 60 days. The maximum extensive efficacy – 90 % and intensive efficacy from 63.54 % to 83.33 % respectively were found in the groups of animals dehelmintized with: «Albendozole 10 %» in the form of suspension for oral administration and the injectable «Santomectin»; these antiparasitic drugs have a similar mechanism of action on helminths. The use of the latter is more cost-effective for agricultural enterprises, which must be taken into consideration when planning the combat measures against trematode infestations in cattle.