GENDER ASPECT IN THE POSTOPERATIVE DYNAMICS OF CHANGING HEMOSTASIS SYSTEM PARAMETERS IN HEALTHY DOG

Abstract

Based on the data obtained earlier, we suggested that the hemostatic system responsed to tissue damage and, especially, the blood vessels at surgery can vary in females and males. 12 clinically healthy dogs of different breeds aged 1 to 8 years, including 6 females and 6 males participated in the study. Blood for hematology and hemostasis tests we have taken before and immediately after the operation, during the animal was in a state of general anesthesia. As a result, we have found out that the system of hemostasis of males and females reacts to injury and stress associated with surgery in different ways. In females more expressed loss of blood, but less the platelet of amount and function changing. In males ristomycin-induced aggregation increased, but disaggregation and antithrombin activity decreased and a level of fibrinogen аnd soluble fibrin complex significantly increased. At the same increasing of thrombus formation in males in the postoperative period we did not observe. Consequently this changes in the hemostatic system in healthy dogs of both sexes have the bleeding stop function under stress and may be the mechanism of adaptation to surgical trauma. Nevertheless, there is every reason to talk about the increased risk of hypercoagulable states in males during surgery