РОЛЬ ПРОВОСПАЛИТЕЛЬНЫХ МЕДИАТОРОВ В РАЗВИТИИ СЕПТИЧЕСКИХ ОСЛОЖНЕНИЙ У ЖИВОТНЫХ

Abstract

Typical clinical manifestations of obstetrical and gynecological sepsis in dogs in the postpartum period are either absent or slabovyrazheny that, apparently, this is due to immunological areactivity this period. Septic complications in female dogs are characterized by complex pathophysiological mechanisms of development. In response to intense microbial load and intoxication by bacterial toxins in animals is a cascade of metabolic changes that characterized the development effects of oxidative stress, the release of a large number of pro-inflammatory cytokines, damage to the vascular endothelium, the development of immunopathological reactions. All this ultimately leads to disruption of the functioning of an organ, systemic, and organismic level.