ВЛИЯНИЕ ЭКЗОГЕННЫХ ГЛИКОЗАМИНОГЛИКАНОВ НА МОРФОЛОГИЮ МОЧЕВОГО ПУЗЫРЯ КРЫС В УСЛОВИЯХ ЭКСПЕРИМЕНТАЛЬНОГО ЦИСТИТА
Abstract
Cystitis on the domestic animals is often treated with exogenous glycosaminoglycans such as heparin,
chondroitine sulphate, or the N-acethyl glycosamine (Furinaid®, TRM). The mechanism of action is presumed
to be due to a coating of the bladder surface to replace the normally present chondroitine sulphate and
glycosamine lost as a result of the disease. This study used experimental damage of the bladder at rats, with
an injection vinegar acid. As a result was revealed a protective effect of glycosaminoglicans for chemical
cystitis. Was observed best hystochemical determination of glycosaminoglicans in bladder mucous with
using a special methods.
chondroitine sulphate, or the N-acethyl glycosamine (Furinaid®, TRM). The mechanism of action is presumed
to be due to a coating of the bladder surface to replace the normally present chondroitine sulphate and
glycosamine lost as a result of the disease. This study used experimental damage of the bladder at rats, with
an injection vinegar acid. As a result was revealed a protective effect of glycosaminoglicans for chemical
cystitis. Was observed best hystochemical determination of glycosaminoglicans in bladder mucous with
using a special methods.
Keywords
577.152:611.62:616.6:619
About the Author
Владислав Соболев
Санкт-Петербургская Государственная академия ветеринарной медицины
Russian Federation
Russian Federation
References
1. Гуцол А.А., Кондратьев Б.Ю. Практическая морфометрия органов и тканей: Для врачей патологоанатомов.- Томск: Изд-во Том. ун-та, 1988.- 136с.
2. Малашко В.В. Гистологические и морфометрические методы исследования/ Белорус. С.-х. акад. - Горки, 1993.- 24 с.
3. Grist M, Chakraborty J: Identification of a mucin layer in the urinary bladder. Urology 1994, 44, P.26- 33.
4. Hurst RE, Rhodes SW, Adamson PB, Parsons CL, Roy JB: Functional and structural characteristics of the glycosaminoglycans of the bladder luminal surface. J Urol 1987, 138, P.433-437.
5. Hurst RE, Zebrowski R: Identification of proteoglycans present at high density on bovine and human bladder luminal surface. J Urol 1994, 152, P.1641-1645.
6. Hurst RE, Roy JB, Parsons CL: The role of glycosaminoglycans in normal bladder physiology and the pathophysiology of interstitial cystitis. In Interstitial Cystitis Edited by: Sant GR. Philadelphia, Lippincott-Raven; 1997, P.93-100.
7. Kimberly D Kyker, Jean Coffman and Robert E Hurst. Exogenous glycosaminoglycans coat damaged bladder surfaces in experimentally damaged mouse bladder. BMC Urology 2005, 5:4 doi:10.1186/1471-2490-5-4
8. Merete Holm-Bentzen, Thorkil Ammitzbшll , Tage Hald. Glycosaminoglycans on the surface of the human urothelium: A preliminary report Neurourology and Urodynamics .1986, 5 :6 , P.519 - 523
9. Nickel JC, Cornish J: Ultrastructural study of an antibody-stabilized bladder surface: a new perspective on the elusive glycosaminoglycan layer. World J Urol 1994, 12, P.11-14.
10. Parsons CL, Housley T, Schmidt JD, Lebow D: Treatment of interstitial cystitis with intravesical heparin. Br J Urol 1994, 73, P.504-507.
11. Parsons CL, Stauffer C, and Schmidt JD. Bladdersurface glycosaminoglycans: an efficient mechanism of environmental adaptation. Science, Vol 208, Issue 4444, P. 605-607
12. Steinhoff G, Ittah B, Rowan S: The efficacy of chondroitin sulfate 0.2% in treating interstitial cystitis. Can J Urol 2002, 9, P.1454-1458.
13. Theoharides TC, Vakali S, Kempuraj D, Sant R. A retrospective open label study of CystoProtek in Painful Bladder Syndrome/Interstitial Cystitis (PBS/IC) Proceedings NIDDK International Symposium: Frontiers in Painful Bladder Syndrome and Interstitial Cystitis (October 24-27, 2006; Bethesda, MD).
14. Theoharides TC, Sant GR. A pilot open label study of CystoProtek in Interstitial Cystitis. International Journal of Immunopathology and Pharmacology, vol. 18, P. 183-188, 2005
Review
For citations:
. Russian Journal of Veterinary Pathology. 2010;(2):35-38. (In Russ.)
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