Infectious diseases play a leading role in the human pathology and mortality as before. Infectious diseases
associated with the steady and close contact with animal-companions are significant. Ten-years monitoring
of the most spreading pathogenes in the materials from domestic animals (basically cats and dogs) was
carried out. Totally 4103 animals observed for different reasons in veterinary clinics were investigated. The
following methods were used: direct and indirect immunofluorescence test, cultivation of microorganisms,
polymerase chain reaction, direct electron microscopic indication of viral pathogenes The prevalence of various
pathogenes was as follow: 30% of cats and 4% of dogs were infected by Toxoplasmes; 8,3% of dogs by
Borrelia; 33,3% of dogs and 20,3% of cats by Mycoplasmes; 19,3% of cats by Bartonella; 40,0% of cats and
37,6% of dogs by Chlamydia; 57,2% of observed animals, by various viruses (adeno-, parvo-, calici-, herpes-
, reo-, myxo- and paramyxo-, coronaviruses and canine distemper virus). Among the last animal group the
mixt viral infections were very significant (31,3% of dogs and 21,3% of cats). Moreover, some animal viral
infections were associated with helmintic and protozoan invasions with addition of the significant diversity
of microbial intestinal community. Now the participation of animal - companions pathogenes in the host infectious
pathology is moderate, but it is necessary to consider that the true level of the prevalence of infectious
agents is substantially higher in comparison with registered. Moreover in connection with the import
into Russia of new animal - companions races and species it is possible to expect the raise of the level of infectious
diseases caused by agents none traditional for our country.

Disease incidence of dogs babesiosis reached 42% concerning other pathologies in 2003, for comparison in
2002 - 21%. Area of tick-transmitterliving has extended. The connection between the form both size of
the parasite and severity of disease is revealed. Phagocytosis rate parameters were determined in blood of
dog suffering from babesiosis. It has been established, that phagocytyc activity are depended on severity of
disease. Both phagocytyc index and phagocytyc number at mild uncomplicated and severe uncomplicated
babesiosis were increased, when as at complicated babesiosis these parameters were lower, than at healthy
animals. There were anaemia (decrease of quantity of erythrocytes and haemoglobin), leucocytosis (eosinophilia,
shift of nucleus to the left with increase young and polymorphonuclear neutrophiles, monocytosis)
in peripherial blood.

We confirmed, that degree of involving different members of population (including species of domestic animals)
in epizootic manifestation of chlamydioses is very difficulty.

There is a specific set of the diseases different kinds of animals and the factors (the conditions), promoting
their origin, spreading and liquidations, in different regions and administration points. It is necessary to consider
in correction (the improvement) system of measures on struggle against epizootic.

We confirmed, that the manifestation of mixed infections caused more heavy current of diseases.
It enlarges percent of post infection complications and level of mortality amongst sick animals.

The data, received by us, has a big practical meaning, because it allow to accelerate the time of diagnoses on
chlamydioses at the early stages of development of infection process by method of differentiation particularities
(clinical and epizootic) of this pathology.

It is confirmed, that the management of epizootic process of animals contagious diseases on the territory of
cites and in agricultural units conditions implicates making the clear and efficiency system of epizootic surveillance
and control, which will promote to epizootic favorable on the territory.

We installed, that the mixed infection (chlamydioses + mycoplasmoses), spontaneous spreading in population
of meat-eating animals reveals itself by wider complex of symptoms of morphological and functional
deflections and changes both in separate organs and integer systems of organs.

S. hyicus is worldwide known as causative agent of exudative epidermitis in pigs. The disease is characterized
by a general infection of the skin, exfoliation and vesicle formation. S. hyicus is part of the normal skin
flora of pigs, cattle and poultry. A strains of S. hyicus producing exfoliative toxins type A, B, C and D (exhA,
exhB, exhC and exhD). 12 Pigs were experimentally inoculated with toxin producing S. hyicus strains DSM
20459, 1289D-88, 6407/01 and K-10. By clinical observations of the skin alterations, all pigs revealed development
of generalized exudative epidermitis. 2 pigs were experimentally inoculated with no toxin producing
S. hyicus strain K-2. The result of this study show that toxin producing strains S. hyicus may cause exudative
epidermitis in pigs.

Results of infection M. kansasii, M. phlei, M. fortuitum, M. xenopi, M. gordonae of guinea pigs and mice by different
methods are given here. Have been determined some pathological changes typical for several species.

On the base of the monitoring of the world gene banks EMBL and GenBank using the RCR method the
high sensitive testing system for diagnostics of the bovine leukemia virus (BLV) was developed and approved
for the testing of 1250 animal samples. Introduction of the developed system in the farm Klenovo-
Chegodaevo made it possible in 6.5 times to decrease the percent of the infected animals among the 6
months old calves. Thus the using of the PCR together to anti-leukemia measure provides the earlier and
fuller detection of the infected animals and decreases the period of the full recovery of the flock.

Implementation of preventive control schema agaust acute respiratory inffections in estations and substantially
reduces the economic damage caused by them. For mazimum affect its etessary to conduct the immunization
of targel population only after obtaining the unding of serologic investigations with permanent
control of immunity challenge by vaccinated animal.

There is a short resume of Brucella specific prophylaxis in this article. Advantages and defects of alive
and killed vaccines from normal (S) and dissociated (S-R, R-S and R) strains are described. Data Brucella
cultures stability are expounded and gave a conception about perspective strains for vaccine preparation.
Immunobiological properties of Brucella virulent strain protective antigen, conjugated with polymeric
carrier are described.

So, in absense of clinical manifestations (abortis, endometritis, vulvovaginitis) and antigens of causative
agents it is recommended to take complex medicines: tetracyclinum-PVP, levoerytromycynum-PAG at
carriage of microorganisms associated in various junctions: chlamidia, leptospira, salmonella, rickettsia,
mycoplasma, virus IRT-PV.

The main link in the control of epidemics of the animal tuberculosis is the desease diagnostic. PCR has been
appliend for the diagnostic of many infection deseases in recent years. However for the diagnostic of cattle
tuberculosis the PCR method didn`t widely. The purpose of our work was a determination of thr possibility
of using of the PCR method in the diagnostic of goats tuberculosis. It is established, that the PCR method
is not effective of goat tuberculosis. The investignation of the pathological material from goats has enabled
to make a diagnostic of the availability of the tuberculosis agent. It is confirmed by the rusults of the
bacteriological researches.

As a result of carrying out of a comparative estimation of sensitivity of five tests-systems for ПЦР- diagnostics
of a tuberculosis of the animals used in veterinary science it is established, that the least sensitive is the
test system of Institute of molecular genetics of the Russian Academy of Science.
If necessary simultaneous indication and differentiation of activators of a tuberculosis of animals, it is the
most expedient to use test-system for revealing and differentiations of activators of a tuberculosis a method
polimerase chain reaction of manufacture NPO «NARVAK». For indication of activators of a tuberculosis
of animals the test-system is more preferable to revealing DNA Mycobacterium tuberculosis complex
manufacture ЦНИИЭ.

Helminth diseases of dogs and cats are widely spread in Russian Federation. Some of them are common for
people and animals. Helminth diseases are very dangerous for animals health especially for pups and kittens.
For effective treatment and preventive maintenance of helminthosis the new drug - prazicid suspension
with a wide spectrum of activity was offered. The drug was shown high efficacy against nematodes and
cestodes of dogs and cats.

Happen to the results of the toxicological studies of the preparation morenit. It is installed that on «Bad
material», he it is classified as little toxins and pertains to 4-mu class to dangers (the small hazmats). The
Given experiment have not revealed the contraindication to using the preparation morenit in stock-breeding
and veterinary medicines.

After using the preparation was restored not only contents protein-fixed iodine in blood, but also correlation
T3 and T4 in blood. Thereby, given preparation can be recommended as facility for preventive maintenance
and treatments to iodine insufficiency beside dogs.