Colibacteriosis in pig farms is reflected in the super-sharp, acute, sub-acute and chronic forms. The source
of the causative agent of disease is sick and affected piglets-Sosunov, podsvinki and sows - bakterionositeli.
The main way of infection is alimentary and airborne path. Colibacteriosis very often proceeds in the form
of mixed infections with vector-borne gastroenteritis and rotaviral disease of pigs. Derivatives of furan and
hynoxalin, gentamicin, laevomycetinum, tetracycline, ciprofloxacin possess the highest antibacterial activity
against Escherichia coli and Salmonella, causing the bacterial disease in pigs.

The results obtained show that cattle cerebrospinal fluid as biologically active substance can be used for
correction certain physiological and pathological states. Data prove advanced use of cerebrospinal fluid in
cell bioengineering.

Aiming at identification of tissue and species origin of mammalian cell lines collected at Ivanovsky Institute
of Virology, Russian Academy of Medical Sciences, we analyzed 31 cell lines initially isolated in the institute
or donated by collaborators. The species-specific polymerase chain reaction and direct sequencing of mitochondrial
DNA demonstrated that in 5 cases the species origin of the cell line has been misinterpreted. The
detailed protocols of the techniques used for DNA-based species identification are presented.

In this article are adduced findings of psychrotrophic microflora of microbiocenosis of suckling farm. The
psychrotrophic microflora can be used, as an indicator of microbiological class of frappe milk.

Adrenalinic functional test causes shifts in pigs of 2 months in indicators of a functional condition simpatoadrenalovoj
the systems which character depends on an initial vegetative tone in the cardiovascular system,
organism of pigs depending first of all from a condition. At healthy pigs the balanced influence of sympathetic
and parasympathetic system on cardiovascular system is in overwhelming majority observed, and in
reply to adrenalinic test there is a strengthening of work of a myocardium that the shock volume of blood is
accompanied by increase. At mikotoksikos at pigs prevails sympathetic influences on cardiovascular system
whereas at mikotoksikos influence on cardiovascular system prevails parasympathetic.

In article results of studying M. avium, received in Siberian region, with use PCR-analysis and sequencing
a mig-gene fragment are resulted.

The dynamics of the immunocompetent cell response and the intensity of creation of antibodies to Mareks
disease vaccine on the basis of turkey herpesvirus were studied. The lymphocyte migration inhibition test
for determination of antigen-induced migration level (ML) and indirect solid-phase immunosorbent assay
for determination of serum antibody titre (T) were used. It was shown that by day 28 the migration level in
SPF chicks was ML±G=0,38±0,09 and in commercial broiler chicks it was ML±G=0,13±0,059. Moreover, the
antibody mean titre in SPF chicks was 1:190 by day 7 and 1:1445 by day 63. In broiler chicks with the mean
titre of transovarian antibodies 1:8590 by day 7 it was demonstrated that the active immune response was induced
by day 35 (titre 1:358); by day 56 the titre was equal to 1:2692. Coefficients of correlation (R±m) between
lymphocyte migration inhibition test and indirect solid-phase immunosorbent assay were determined
and at the phase of the development of active immune response in SPF chicks and broiler chicks they made
up 0,814±0,111 and 0,840±0,136, correspondingly.

The use of enroflone in dose of 1 ml/10 kg of body mass inside, gentamicin - in dose of 2 ml/10 mg and benzilpenicillin-
10 thousand ed/kg of body mass, 2 times a day intramuscularly against colibacteriosis ensures
100% efficiency.

A relatively high resistance frequency (30-53.8%) of Staphylococcus intermedius strains to benzyl penicillin,
ampicillin, streptomycin, cephepim, kanamycin, and lincomycin has been revealed.
The results of the study have shown all the staphylococcus strains to be susceptible to amoxycillin, inhibitorprotected
penicillins, carbapenemes, cefazolin, furagin as well as to the majority of fluoroquinolones.

The microbiocenosis of tropic fish at norm and pathologic were studied. The surface at the body healthy fish
have solitary bacterium (6,6-13,3 CFU/sm2). Internal organs were free from micro flora. There are a considerable
account of bacterium (104,0-286,0 CFU/g) in the liver of fish at septic bacteriosis. Invasion of fish by
Trichodina, Cryptobia and Costia accompanied by exogenous sepsis.

Our results concluded that irradiated Ars-Ga и He-Ne laser has cryoprotactive effect on the ram semen
storage at 4°С.

It is established that a preparation glikopin exerts immunostimulation influence on increase of indexes of
cellular and humoral immunity, and as on the natural resistance of newborn calves. Considerably raises efficiency
of antibacterial preparations and essentially reduces their course dose.

It is established that a preparation Glikopin exerts immunostimulation influence on increase of indexes of
cellular and humoral immunity, and as on the natural resistance of newborn calves. Considerably raises efficiency
of antibacterial preparations and essentially reduces their course dose.

Authors (N.A. Kazakov and M.F. Idina) detected bovine anaplasmosis (A. marginale) for the first time in
Tver region. Earlier this region was known as tree trom this agent.
Correctly put diagnosis is base for successful control of the disease.

The parasitic system babesiasis of large horned cattle in conditions of the Nizhniy Novgorod area has regional
features of the display in territorial, temporary measurements.

Thus, antiparasitic pastes Alezan and Panacur in therapeutic does not render a doze of negative influence
on a clinical condition and biochemical parameters of blood of horses.

In article it is cited data on mixed infection of intestinal helminthoses of horses and their role in formation
of nozoprofil of infection pathologies of horses in facilities of the Nizhniy Novgorod area with an individual
pattern of ownership.

The drug Аlben forte in the form of suspension is a 4-class low emissions. LD50 is introduced into the stomach
in white mice is 5000 mg / kg. The drug is poorly expressed cumulation. Cumulation ratio is 3.04. Do not
have sensitizing properties. In subchronic experiments (within 2 months), the drug does not cause signs of
toxicity and death in calves and lambs.

The carried out research of local - irritant, skin - resorvent and allergic effect of injection form of drug induding
enrofloxacin and colistin in animals. It has slight irritant effect on the skin and doesnt have any skin
- resorvent and allergic properties.

We studied the influence of the drug on the basis of composite Еnrofloxacin and colistin at doses 0.5, 1.0
and 5.0 ml per 10 kg bodyweight on the clinical and biochemical indices of the blood in piglets and calves. It
was found that the therapeutical efficacy of new drug in calves with colibakteriosis equaled 90,7%, piglets -
91,4%, while the efficacy of Dizparcolum (base product) was 78.9% and 80.0% respectively.

Immunotropnye prepations are used at immunodeficiencies of a various aetiology. In veterinary practice
them apply in an initial stage of development of infectious diseases; to young growth in the first days after a
birth; during the first and third periods of pregnancy of females; for increase of intensity of immunity at vaccination;
at treatment of illnesses of an infectious and noncontagious aetiology.

Indirect ELISA provides specific antibody in swine sera, vaccinated against classical swine fever.

A brief report of the Department for veterinary pathology of the Russian people friendship university on
researches for 2006-2008 is presented in the paper. The results and objective data in three trends having important
significance for veterinary science, practice and education were approached: epizootological investigations
in exotic regions, actual problem